This is my first build, switching over from laptops and I'm quite pleased with the result. Desk space is at a premium so I chose a case with a very vertical layout and small footprint. This case has a bad rep online for running hot, but this new revision with mesh side panels should help with that. The case comes with a riser cable that allows the GPU to be mounted back-to-back with the motherboard. This will cause issues if the PCIe slot is running gen 4, so I had to disable auto detection and force it to run at gen 3 in the BIOS, which from what I understand is not an option on all X570 boards.
I bought the RAM before switching out the motherboard to one that was in stock (and had the PCIe setting). This new motherboard doesn't support the onboard 3600MHz XMP profile, so I had to tune it up to 3200MHz manually. It might be possible to run it at 3600MHz, but that's higher than the max listed in the manual and I was getting blue-screens as soon as it booted.
I've also ran into some issues with the AIO because of the unconventional positioning in the Shift. Sometimes a bubble will form the highest point in the loop, which is unfortunately the pump. When it happens I've been able to get it all working smoothly again by laying the case on its side for a bit. So far this has only happened after I shake around the case making changes to components and when I left for 10+ days during the holidays.
In terms of thermals, I set up the top-front fan as exhaust and the bottom radiator as intake. The CPU cooler has no problem keeping it below 70c, which is the temperature configured to trigger max CPU fan speed in the BIOS. The GPU temps could be better. Although the standard temperature reading stays pretty stable at 80, the "hot spot" goes up to 110c when under load, but drops immediately if I tab out of a game or stop a stress test.