Hopped onto the itx bandwagon, used for HTPC, light gaming @ 1920x1080 (Bioshock, Skyrim, Borderlands, Dolphin etc.), Plex server.
Runs everything surprisingly well, 45+ FPS with BL2 and Bioshock on ultra with no noticeable frame drops. Skyrim runs 60+ on ultra, Dolphin is maxing out at 60 FPS. It pulls around 40 watts idle and 80 watts running prime95.
The case is tiny, if you haven't seen the pictures yet. There are no cable management options and airflow is nearly stagnant stock so I did my best and cleared the space between the heatsink and the 4x40mm fans. Modified and mounted an 80mm fan to the side (there were no holes for it and it was hitting the HDD) to cool the GPU and HDD. Machined a new adapter plate for the SFX PSU as I didn't have enough clearance to put a side blowing tower cooler (to direct the air to the back into the 4x40mm fans).
I may have overpaid for performance I got but it's the price I paid for going small.