I use this build for daily work involving programming, compiling and VMs. I went for an OEM RX 460 GPU in the end.
Generally runs well, no major issues found. Would be nice to have another place for the 3rd fan. Also note the case comes with a fan, but I swapped it out because mine are better.
I will probably add an aftermarket cooler in a bit - it runs pretty hot under load, but apparently this is normal and okay. 40-60C when idle and 80-94C under load! It does thermal throttle a little bit, but it doesn't matter too much for me. I undervolted it by 50mV to get it to run a bit cooler. No stability issues thus far.