I use this machine as a workstation. Primarily for statistical computing. It's running Ubuntu 12.10/13.04 64bit
I didn't have any problems putting it together with the exception of the cooling unit.
The ASUS Motherboard has a heatsink at the top that forces you to jimmy rig the attachment of the H100i. I couldn't use the provided screw slots in the case for the radiator and had to make my own holes, adjusting the radiator and fans closer to the window side of the case and away from the motherboard.
It should also be noted you have to hook up the CPU power supply and fan BEFORE you attach the radiator/fans to the case, otherwise you will not have access to them.
When I initially started the computer, the fans run at full speed. Corsair Link, not being available for linux made this somewhat of an annoyance. However, simply attaching the fans as chassis fans instead of using the y-connector off the head of the H100i worked well and now I'm running at a cool 32 degrees celsius with practical silence (controlling the fans through profiles with lm-sensors, and fancontrol)
The only other problem is that the motherboard does not have onboard USB 3.0 headers, so I've had to order another part (not received yet) to be able to use the USB 3.0 connections on the front of the case (http://www.newegg.ca/Product/Product.aspx?Item=N82E16815256001)
Overall it took me about 4 hours to put together (first timer!). It's running great so far - an incredible boost from my last computer. (HDD, i7-890, ATI Radeonb HD 5670).