The only physical problem I had was that the heat spreaders on the ram interfered with the largest daughterboard on the Mobo. I resolved this by removing shielding that appears to be cosmetic. I have been able to overclock both the GPU and CPU relatively easily. With even a water cooling kit like the H60 I can overclock the crap out of the CPU without the temps getting out of control. Overall, I am very happy with the setup. I am running triple monitors at 1080p and am able to Run Crysis 3 in Nvidia surround at 45 fps if I set the AA to medium and everything else maxed. Obviously I am able to run any current game at max settings on a single monitor as well.