I use this beast for everything, and it handles everything. Haven't run into any major issues yet but I'll soon be adding a 200mm blue LED side fan, and getting a better CPU cooler, especially since OC'ing. One thing I did notice about the case, is the fact that sometimes under stress, the whole thing will vibrate a little and the side panel actually makes a lot of annoying noise from that. Otherwise, all is well. Thinking of sticking sound-controlled lights in there too... :D
Edit 11/2013 -- Added 200mm Cooler Master blue LED fans to the side and top, and upgraded the cooler. Everything is still running well and I'm soon expecting to install a 3TB drive and second graphics card in SLI since prices have gone way down. As for the vibrations, seems like that's just a thing of the past. Now have a second monitor, thinking about getting a third. Got a new Cooler Master mechanical keyboard and Anker mouse, the mouse is yet to be added to PPP's database.