Last year during the summer my Radeon 4850 bit the dust, so I replaced it with a XFX 7950. Shortly after, I decided to upgraded my cpu from an AMD Phenom II 955 to an FX-8350, so I had to get a new motherboard. At this point I had already upgraded the majority of the computer parts and decided to just build a new computer. I purchased a new case and power supply as well.
So far, I am pleased with this build as it does everything I ask it to do. I run 24" and 27" monitors at 1920x1200. I have the SSD with Windows and any other frequently used programs. The 500GB drives are in RAID 0. I install all other programs onto this array. The 1TB drive is purely for media files and saved documents.
I had hoped to run crossfire with my 7950, but it might be better just to upgrade to a newer card and sell my existing card. However, I probably won't do this for at least a year or two.